Placental growth factor as potential target against hepatocellular carcinoma in an orthotopic mouse model.

ABSTRACT: The placental growth factor (PlGF) is member of the vascular endothelial growth factor (VEGF)-family known to stimulate endothelial cell growth, migration and survival, attract angiocompetent macrophages and bone marrow progenitor cells and determine the metastatic niche. Unlike VEGF, genetic studies have shown that PlGF is specifically involved in the pathologic angiogenesis, thus its inhibition would not affect healthy blood vessels, providing an attractive drug candidate with a good safety profile. In this study, we assess whether inhibition of PlGF could be used as a potential therapy against hepatocellular carcinoma (HCC), by using PlGF-knock out mice and monoclonal antibodies targeting PlGF in an orthotopic model for HCC. In addition, the effect of PlGF-antibodies is compared to that

ORGANISM(S): Mus musculus

SUBMITTER: Wouter Van Delm 

PROVIDER: E-GEOD-35289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress