Transcription profiling of adult mouse heart following activation of Ras, MKK3 and MKK7 mutant genes

ABSTRACT: Three major MAP kinase signaling cascades, ERK, p38 and JNK, play significant roles in the development of cardiac hypertrophy and heart failure in response to external stress and neural/hormonal stimuli. In order to study the specific function of each MAP kinase branch in adult heart, we have generated three transgenic mouse models with cardiac specific and temporally regulated expression of activated mutants of Ras, MKK3 and MKK7, which are selective upstream activators for ERK, p38 and JNK, respectively. Gene expression profiles in transgenic adult hearts were determined using cDNA microarrays at both early (4-7 days) and late (2-4 weeks) time points following transgene induction. From this study, we revealed common changes in gene expression among the three models, particularly invol

ORGANISM(S): Mus musculus

SUBMITTER: Scherise Mitchell 

PROVIDER: E-GEOD-3530 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress