Expression data from tail skin in young (5 months) and old (30 months) CB6F1 mice

ABSTRACT: Background: Skin aging is associated with intrinsic processes that compromise structure of the extracellular matrix while promoting loss of functional and regenerative capacity. These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood and conservation of these mechanisms between humans and mice is uncertain. Results: We used genome-wide expression profiling to investigate the aging skin transcriptome. In humans, age-related shifts in gene expression were sex-specific. In females, aging increased expression of transcripts associated with T-cells, B-cells and dendritic cells, and decreased expression of genes in regions with elevated Zeb1, AP-2 and YY1 motif density. In males, however, these effects were contrasting or absent.

ORGANISM(S): Mus musculus

SUBMITTER: William Swindell 

PROVIDER: E-GEOD-35322 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress