Transcriptomic profiling of choroid plexus in experimental autoimmune encephalomyelitis

ABSTRACT: Multiple sclerosis (MS) is a demyelinating disease causing major neurological disability in young adults. We characterized the transcriptome of the choroid plexus (CP), which is part of the blood-brain barriers and the major site of cerebrospinal fluid (CSF) production, in the experimental autoimmune encephalomyelitis mouse model of MS. Genes encoding for adhesion molecules, chemokines and cytokines displayed the most altered expression, supporting the CP as a site of immune-brain interaction in MS. The gene encoding for lipocalin 2 (LCN2) was the most up-regulated, and CSF LCN2 levels coincided with the phases of active disease. Total RNA was isolated with Trizol (Invitrogen, Carlsbad, CA, USA) following the manufacturer’s instructions. After quality assessment using the Agilent Bioanalyz

ORGANISM(S): Mus musculus

SUBMITTER: Giovanni Coppola 

PROVIDER: E-GEOD-35363 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress