Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance

ABSTRACT: Background. Differential gene expression in adipose tissue during diet-induced weight loss followed by a weight stability period is not well characterized. Markers of these processes may provide a deeper understanding of the underlying mechanisms. Objective. To identify differentially expressed genes in human adipose tissue during weight loss and weight maintenance after weight loss. Design. RNA from subcutaneous abdominal adipose tissue from nine obese subjects was obtained and analyzed at baseline, after weight reduction on a low calorie diet (LCD), and after a period of group therapy in order to maintain weight stability. Results. Subjects lost 18.8 + 5.4% of their body weight during the LCD and maintained this weight during group therapy. Insulin sensitivity (HOMA) improved after we

ORGANISM(S): Homo sapiens

SUBMITTER: Anders Danielsson 

PROVIDER: E-GEOD-35411 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress