Genome-wide analysis of gene expression changes in miR-214 KO mouse hearts and skeletal muscle

ABSTRACT: Early reperfusion of ischemic cardiac tissue remains the most effective intervention for improving clinical outcome following myocardial infarction. However, abrupt increases in intracellular Ca2+ during myocardial reperfusion cause cardiomyocyte death and consequent loss of cardiac function, referred to as ischemia/reperfusion (IR) injury. Cardiac IR is accompanied by dynamic changes in expression of microRNAs (miRNAs), which inhibit specific mRNA targets. miR-214 is up-regulated during ischemic injury and heart failure in mice and humans, but its potential role in these processes is unknown. We show that genetic deletion of miR-214 in mice causes loss of cardiac contractility, increased apoptosis, and excessive fibrosis in response to IR injury. The microarray contains 6 samples, eac

ORGANISM(S): Mus musculus

SUBMITTER: Arin Aurora 

PROVIDER: E-GEOD-35421 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress