Gene expression analysis of U251 human glioblastoma cell line

ABSTRACT: The human TP53 gene is frequently mutated in tumors and cell lines. Unlike other tumor suppressors that are commonly inactivated by deletions or nonsense mutations, the majority of p53-mutations are missense point mutations that result in the expression of a full-length protein with an altered amino acid that has lost sequence specific DNA-binding. Expression of mutant p53 (mutp53) confers advantages to tumor cells and transcriptional regulation of several genes mediating the beneficial effects has been shown to play a role. However, molecular mechanisms of transcriptional regulation by mutp53 are still poorly understood. We used the glioblastoma-derived U-251 MG human cell line endogenously expressing mutp53 protein (R273H mutation) to analyze gene expression profiles on Agilent Whole Hum

ORGANISM(S): Homo sapiens

SUBMITTER: Genrich Tolstonog 

PROVIDER: E-GEOD-35454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress