Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines

ABSTRACT: Gastric adenocarcinoma is one of the major malignancies worldwide. Gastric cell lines have been widely used as the model to study the genetics, pharmacology and biochemistry of gastric cancers. Here we describe a comprehensive survey of the gene expression profiles of 12 gastric carcinoma cell lines, using cDNA microarray with 43 000 clones. For comparison, we also explored the gene expression patterns of 15 cell lines derived from lymphoid, endothelial, stromal and other epithelial cancers. Expression levels of specific genes were validated through comparison to protein expression by immunohistochemistry using cell block arrays. We found sets of genes whose expression corresponds to the molecular signature of each cell type. In the gastric cancer cell lines, apart from genes that are high

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Chen 

PROVIDER: E-GEOD-3547 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress