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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genes regulated by Sox9

ABSTRACT: We compared gene expression profile of jejunum crypt samples of Sox9 deficient mice and wild type control mice in order to identify the genes that are regulated by SOX9 in the small intestinal crypt epithelial cells. The intestinal epithelial cells were collected from crypts of jejunum of three 3-mo-old Sox9 mutant mice and three littermate controls.

ORGANISM(S): Mus musculus

SUBMITTER: Toni-Ann Mistretta

PROVIDER: E-GEOD-35481 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genes regulated by Sox9

Project description:We compared gene expression profile of jejunum crypt samples of Sox9 deficient mice and wild type control mice in order to identify the genes that are regulated by SOX9 in the small intestinal crypt epithelial cells.

2012-03-23 | GSE35481 | GEO

Comparison of Sox9-EGFP cell type transcriptomes during irradiation-induced crypt regeneration

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Sox9 directs divergent epigenomic states in brain tumor subtypes

Project description:Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic alterations, however the molecular mechanisms responsible for these diverse epigenetic states remain unclear. Here we show that the developmental transcription factor Sox9 differentially regulates epigenomic states in high-grade glioma (HGG) and ependymoma (EPN). These contrasting roles for Sox9 correspond with protein interactions with histone deacetylating complexes in HGG, and association with the Rela oncofusion in EPN. Together, our studies demonstrate how epigenomic states are differentially regulated in distinct subtypes of brain tumors, while revealing divergent roles for Sox9 in HGG and EPN tumorigenesis.

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Mouse intestinal crypt epithelial cells: Apc+/Î716 mice vs. Apc+/Î716 Id2-/- compound mutant mice

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RNA-seq of crypt and villus cells from mouse small intestinal epithelium with an intestinal-epithelial specific deletion of LSD1 compared to wild type controls

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Single intestinal stem cells build crypt-villus structures in vitro without a cellular niche

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