Expression data from human with IgA nephropathy (IgAN) [HG-U133A_ENTREZG_10]

ABSTRACT: Proteinuria is the most important predictor of outcome in glomerulonephritis and experimental data suggest that the tubular cell response to proteinuria is an important determinant of progressive fibrosis in the kidney. However, it is unclear whether proteinuria is a marker of disease severity or has a direct effect on tubular cells in the kidneys of patients with glomerulonephritis. Accordingly we studied an in vitro model of proteinuria, and identified 231 albumin-regulated genes differentially expressed by primary human kidney tubular epithelial cells exposed to albumin. We translated these findings to human disease by studying mRNA levels of these genes in the tubulo-interstitial compartment of kidney biopsies from patients with IgA nephropathy using microarrays. Biopsies from patie

ORGANISM(S): Homo sapiens

SUBMITTER: Celine Berthier 

PROVIDER: E-GEOD-35488 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress