Noncoding RNA expression in myocardium from infants with tetralogy of Fallot [miRNA profiling]

ABSTRACT: This is the first report characterizing noncoding RNA expression in a congenital heart defect. The striking shift in expression of noncoding RNAs reflects a fundamental change in cell biology, likely impacting expression, transcript splicing and translation of developmentally important genes and possibly contributing to the cardiac defect. The importance of noncoding RNAs (ncRNA), especially microRNAs, for maintaining stability in the developing vertebrate heart has recently become apparent. However, there is little known about the expression pattern of ncRNA in the human heart with developmental anomalies. We examined the expression of microRNAs and small nucleolar RNAs (snoRNAs) in right ventricular myocardium from 16 infants with nonsyndromic tetralogy of Fallot (TOF) without a 22q11.2

ORGANISM(S): Homo sapiens

SUBMITTER: Douglas Bittel 

PROVIDER: E-GEOD-35490 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress