VIA of EM CD8 T cells in vaccinated monkeys

ABSTRACT: The goal of an effective AIDS vaccine is to generate immunity that will prevent HIV-1 acquisition. Despite limited progress towards this goal, renewed optimism has followed the recent success of the RV144 vaccine trial in Thailand. However, the lack of complete protection in this trial suggests that breakthroughs, where infection occurs despite adequate vaccination, will be a reality for many vaccine candidates. We previously reported that neutralizing antibodies elicited by DNA prime/rAd5 boost vaccination with SIVmac239 Gag/Pol and Env provided protection against pathogenic SIVsmE660 acquisition after repeated mucosal challenge. Here, we report that SIV-specific CD8+ T cells elicited by that vaccine lowered both peak and set-point viral loads in macaques that became infected despite

ORGANISM(S): Macaca mulatta

SUBMITTER: Francois Lefebvre 

PROVIDER: E-GEOD-35628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress