UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Jie Wang
PROVIDER: E-GEOD-35638 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery.
Zhang Fan F Wang Jie J Xu Jia J Zhang Zhao Z Koppetsch Birgit S BS Schultz Nadine N Vreven Thom T Meignin Carine C Davis Ilan I Zamore Phillip D PD Weng Zhiping Z Theurkauf William E WE
Cell 20121101 4
piRNAs silence transposons during germline development. In Drosophila, transcripts from heterochromatic clusters are processed into primary piRNAs in the perinuclear nuage. The nuclear DEAD box protein UAP56 has been previously implicated in mRNA splicing and export, whereas the DEAD box protein Vasa has an established role in piRNA production and localizes to nuage with the piRNA binding PIWI proteins Ago3 and Aub. We show that UAP56 colocalizes with the cluster-associated HP1 variant Rhino, th ...[more]
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