Transcriptome analysis of a chronic in vitro model of Parkinsonism

ABSTRACT: The pesticide rotenone, a neurotoxin that inhibits the mitochondrial complex I, and destabilizes microtubules (MT) has been linked to Parkinson disease (PD) etiology and is often used to model this neurodegenerative disease (ND). Many of the mechanisms of action of rotenone are posited mechanisms of neurodegeneration; however, they are not fully understood. Therefore, the study of rotenone-affected functional pathways is pertinent to the understanding of NDs pathogenesis. This report describes the transcriptome analysis of a neuroblastoma (NB) cell line chronically exposed to marginally toxic and moderately toxic doses of rotenone. The results revealed a complex pleiotropic response to rotenone that impacts a variety of cellular events, including cell cycle, DNA damage response, prolifera

ORGANISM(S): Homo sapiens

SUBMITTER: Yofre Cabeza-Arvelaiz 

PROVIDER: E-GEOD-35642 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress