A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype (resting muscle after endurance training)

ABSTRACT: The molecular pathways which are activated and contribute to physiological remodeling of skeletal muscle in response to endurance exercise have not been fully characterized. We previously reported that ~800 gene transcripts are regulated following 6 weeks of supervised endurance training in young sedentary males, referred to as the training responsive transcriptome (TRT). Here we utilized this database together with data on biological variation in muscle adaptation to aerobic endurance training in both humans and a novel out-bred rodent model to study the potential regulatory molecules that coordinate this complex network of genes. We identified three DNA sequences representing RUNX1, SOX9, and PAX3 transcription factor binding sites as over-represented in the TRT. In turn, miRNA profiling

ORGANISM(S): Homo sapiens

SUBMITTER: JAMIE TIMMONS 

PROVIDER: E-GEOD-35659 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress