Systemic elevation of PTEN induces a tumor suppressive metabolic state

ABSTRACT: Decremental loss of PTEN results in cancer susceptibility and tumor progression. In turn this raises the possibility that PTEN elevation might be an attractive option for cancer prevention and therapy. We have generated several transgenic mouse lines with variably elevated PTEN expression levels, taking advantage of BAC (Bacterial Artificial Chromosome)-mediated transgenesis. Super-PTEN mutants are viable and show reduced body size due to decreased cell number, with no effect on cell size. Unexpectedly, PTEN elevation at the organism level results in healthy metabolism characterized by increased energy expenditure and reduced body fat accumulation. Cells derived from these mice show reduced glucose and glutamine uptake, increased mitochondrial oxidative phosphorylation, and are resistant t

ORGANISM(S): Mus musculus

SUBMITTER: BIDMC Genomics 

PROVIDER: E-GEOD-35670 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress