ChIP-chip time-course from DmD8 cells with Pol II (Ser 2 and Ser 5 phosphorylated) antibody after 0, 10, 20, 30 40, 60 and 100 minutes Notch activation

ABSTRACT: Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. We have analyzed the temporal changes in transcription following a short Notch activation treatment and related these to the recruitment of the Notch pathway transcription factor, CSL [Suppressor of Hairless, Su(H), in Drosophila], and to the state of RNA Polymerase II (Pol II) binding. A total of 154 genes showed significant differential expression over time and their expression profiles stratified into 14 clusters based on temporal and quantitative differences in their responses. These differences were partially reflected in the profiles of Pol II and Su(H) binding. However, neither could fully account for the different response profil

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sarah Bray 

PROVIDER: E-GEOD-35715 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress