Analysis of striatal transcriptome in transgenic mice overexpressing human wild-type alpha-synuclein

ABSTRACT: Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson’s disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more extensive yet regionally selective neurodegeneration is observed in other synucleinopathies. Furthermore, SNCA is ubiquitously expressed in neurons and numerous neuronal systems are dysfunctional in PD. Therefore it is of interest to understand how overexpression of SNCA affects neuronal function in regions not directly targeted for neurodegeneration in PD. To gain a better understanding of the consequences of excessive SNCA expression on basal ganglia function, we performed transcriptome analysis of striatal tissue from male Thy1-aSyn-mice and wt littermates. The prese

ORGANISM(S): Mus musculus

SUBMITTER: Yofre Cabeza-Arvelaiz 

PROVIDER: E-GEOD-35723 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress