Comparative analysis of S100a10-expressing cortical pyramidal cells and whole cortex

ABSTRACT: Molecular phenotyping of cell types and neural circuits underlying pathological neuropsychiatric conditions and their responses to therapy provides one avenue for the development of more specific and effective treatments. In this study, we identify a cell population in the cerebral cortex that shows robust and specific molecular adaptations following long-term SSRI treatment. We employed the bacTRAP strategy, which uses BAC transgenic mice expressing EGFP-tagged ribosomal protein L10a in specific cell populations, to affinity purify polysome-bound mRNAs from S100a10-expressing corticostriatal projection neurons. We show that the S100a10 cells are a unique population of cortical cells that are strongly and specifically responsive to chronic SSRI administration and that this response requir

ORGANISM(S): Mus musculus

SUBMITTER: Eric Schmidt 

PROVIDER: E-GEOD-35751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress