Systematic Discovery of Structural Elements Governing Mammalian mRNA Stability

ABSTRACT: Decoding post-transcriptional regulatory programs underlying gene expression is a crucial step toward a predictive dynamical understanding of cellular state transitions. Despite recent systematic efforts, the sequence determinants of such mechanisms remain largely uncharacterized. An important obstacle in revealing these elements stems from the contribution of local secondary structures in defining interaction partners in a variety of regulatory contexts, including but not limited to transcript stability, alternative splicing and localization. There are many documented instances where the presence of a structural regulatory element dictates alternative splicing patterns (e.g. human cardiac troponin T) or affects other aspects of RNA biology. Thus, a full characterization of post-transcript

ORGANISM(S): Homo sapiens

SUBMITTER: Hani Goodarzi 

PROVIDER: E-GEOD-35800 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress