Environmentally Induced Epigenetic Transgenerational Inheritance of Somatic Transcriptomes

ABSTRACT: Environmentally induced epigenetic transgenerational inheritance of adult onset disease involves a variety of phenotypic changes suggesting a general alteration in genome activity. Investigation of eleven different tissue transcriptomes in male and female F3 generation vinclozolin versus control lineage rats demonstrated all tissues examined had unique transgenerational transcriptomes. Common cellular pathways and processes were identified among the tissues. A bionetwork analysis identified gene modules with coordinated gene expression and each had unique gene networks regulating tissue specific gene expression and function. A large number of statistically significant over-represented clusters of differentially expressed genes were identified and termed M-bM-^@M-^\Epigenetic Control R

ORGANISM(S): Rattus norvegicus

SUBMITTER: Michael Skinner 

PROVIDER: E-GEOD-35839 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress