Maternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [Bisulfite-Seq]

ABSTRACT: Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxiety-like phenotype in the wild-type offspring by a non-genetic, presumably epigenetic mechanism. Here we tested v-DGCs for genome-wide DNA methylation changes elicited by the receptor deficient maternal environment. We identified a set of hypomethylated regions in the offspring of receptor deficient mothers. A significant fraction of these maternal-differentially methylated regions (m-DMRs) mapped to strong CpG islands, sequences that are typically not methylated or if methylated, resistant to

ORGANISM(S): Mus musculus

SUBMITTER: Miklos Toth 

PROVIDER: E-GEOD-35854 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress