Hypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling

ABSTRACT: Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signaling intersect in promotion of arterial differentiation. Hypoxia upregulated expression of the Notch ligand Dll4 and increases Notch signaling, in a process requiring the vasoactive hormone adrenomedullin but not endogenous VEGF. Notch signaling also upregulated Dll4 expression, leading to a positive feedback loop sustaining Dll4 expression and Notch signaling. In addition, functional Notch signaling was required for hypoxia to upregulate the arterial marker genes Depp, connexin40 (Gja5), Cxcr4 an

ORGANISM(S): Mus musculus

SUBMITTER: Kian Leong LEE 

PROVIDER: E-GEOD-35894 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress