Up-regulation of the peroxisome proliferator-activated receptor alpha and gamma pathway in the intestines of Giardia duodenalis infected calves

ABSTRACT: Despite of Giardia duodenalis being one of the most commonly found intestinal pathogens in humans and animals, little is known of the host-parasite interactions in natural hosts. Therefore, the objective of this study was to investigate the intestinal response in calves following a G. duodenalis infection, using a bovine high-density oligo microarray to analyze global gene expression in the small intestine. The resulting microarray data suggested a decrease in inflammation, immune response and immune cell migration in infected animals, which was examined in more detail by quantitative real-time PCR on a panel of cytokines combined with histological analyses. The cytokine transcription levels showed a trend of down regulated expression in infected animals compared to the negative controls,

ORGANISM(S): Bos taurus

SUBMITTER: Robert Li 

PROVIDER: E-GEOD-35920 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress