Effect of paraquat and nicotine on gene expression in a Drosophila melanogaster Parkinson's disease model

ABSTRACT: Cigarette smoking is associated with reduced risk of developing Parkinson’s disease (PD). To identify genes that interact with nicotine/smoking, we performed hypothesis-free genome-wide experiments in a paraquat-induced Drosophila model and in a case-control study of PD. We demonstrated that nicotine extends life-span in paraquat-treated Drosophila (P=4E-30). Brain tissue from flies treated with combinations of paraquat and nicotine revealed elevated expression of CG14691 with paraquat which was restored with nicotine co-treatment (P(interaction)=2E-11, P(FDR-adjusted)=4E-7). Independently, variants in the 5’ region of SV2C, a human ortholog of CG14691, gave the strongest signal for interaction with smoking (P(interaction)=9E-8). The effect of smoking on PD risk varied six-fold by SV2C

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Haydeh Payami 

PROVIDER: E-GEOD-35930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress