Global Mapping at the Core of the Arabidopsis Circadian Clock Defines the Network Structure of the Oscillator

ABSTRACT: In many organisms, the circadian clock is composed of functionally coupled morning and evening oscillators that regulate the bouts of dawn and dusk activity. In Arabidopsis, oscillator coupling relies on a core loop in which the evening oscillator component TOC1 was proposed to activate a subset of morning-expressed oscillator genes. Our systems-biological approach overturns the current view of the Arabidopsis circadian clock showing that TOC1 does not function as an activator but as a timely-controlled general repressor of morning and evening oscillator components. Repression occurs through rhythmic binding to the promoters of all oscillator genes, suggesting a previously unexpected direct connection between the morning and evening loops. Examination of TOC1 genome-wide binding using TOC1

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Jose Riechmann 

PROVIDER: E-GEOD-35952 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress