Transcriptional regulation by H3K122 acetylation in the lateral surface of the histone octamer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Sebastian Pott
PROVIDER: E-GEOD-35954 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.
Tropberger Philipp P Pott Sebastian S Keller Claudia C Kamieniarz-Gdula Kinga K Caron Matthieu M Richter Florian F Li Guohong G Mittler Gerhard G Liu Edison T ET Bühler Marc M Margueron Raphael R Schneider Robert R
Cell 20130201 4
Histone modifications are key regulators of chromatin function. However, little is known to what extent histone modifications can directly impact on chromatin. Here, we address how a modification within the globular domain of histones regulates chromatin function. We demonstrate that H3K122ac can be sufficient to stimulate transcription and that mutation of H3K122 impairs transcriptional activation, which we attribute to a direct effect of H3K122ac on histone-DNA binding. In line with this, we f ...[more]
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