DNA hypermethylation in placental tissues: placental tissues vs. maternal peripheral bloods

ABSTRACT: Noninvasive prenatal diagnosis currently used does not achieve desirable levels of sensitivity and specificity. Recently, fetal methylated DNA biomarkers in maternal whole blood have been explored for noninvasive prenatal detection. However, such efforts cover only chromosomal aneuploidy; fetal methylated DNA biomarkers for detecting single-gene disease remain to be discovered. To address this issue, we systematically screened significantly hypermethylated genes in fetal tissues compared with maternal blood for noninvasive prenatal diagnosis of various inherited diseases. First, Methylated-CpG island recovery assay combined with CpG island array was performed in four maternal peripheral bloods and their corresponding placental tissues. Subsequently, direct bisulfite sequencing and combined

ORGANISM(S): Homo sapiens

SUBMITTER: Hong Weiguo 

PROVIDER: E-GEOD-35997 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress