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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human macrophages and dendritic cells exposed to phylogenetically distinct parasites

ABSTRACT: Monocyte-derived dendritic cells (DC) and macrophages (MÎ¦) generated in vitro from the same individual blood donors were exposed to five different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct protozoan (Leishmania major, L. donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were examined, each of which produces chronic infections in humans yet vary considerably in the nature of the immune responses they trigger.

Note that the following pairs of files as imported from GEO are identical: GSM5135.txt and GSM5144.txt; GSM5137.txt and GSM5138.txt; GSM5143.txt and GSM5150.txt; GSM5148.txt and GSM5155.txt

ORGANISM(S): Homo sapiens

SUBMITTER: Damien Chaussabel

PROVIDER: E-GEOD-360 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites.

Chaussabel Damien D Semnani Roshanak Tolouei RT McDowell Mary Ann MA Sacks David D Sher Alan A Nutman Thomas B TB

Blood 20030327 2

Monocyte-derived dendritic cells (DCs) and macrophages (Ms) generated in vitro from the same individual blood donors were exposed to 5 different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct protozoan (Leishmania major, Leishmania donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were examined, each of which produces chronic infections in humans yet vary considerably in the ...[more]

PMID: 12663451

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