Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Mantle Cell Lymphoma

ABSTRACT: Gene expression analyis of primary MCL including IGHV mutated and unmutated cases Gene set analysis was perfomed in MCL samples, comparing IGHV mutated cases vs. IGHV unmutated cases In total 38 MCL samples were processed with the HU133plus 2.0 microarray. Twenty four cases had a IGHV mutations and 14 were unmutated.

ORGANISM(S): Homo sapiens

SUBMITTER: Pedro Jares 

PROVIDER: E-GEOD-36000 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features.

Navarro Alba A   Clot Guillem G   Royo Cristina C   Jares Pedro P   Hadzidimitriou Anastasia A   Agathangelidis Andreas A   Bikos Vasilis V   Darzentas Nikos N   Papadaki Theodora T   Salaverria Itziar I   Pinyol Magda M   Puig Xavier X   Palomero Jara J   Vegliante Maria Carmela MC   Amador Virgina V   Martinez-Trillos Alejandra A   Stefancikova Lenka L   Wiestner Adrian A   Wilson Wyndham W   Pott Christiane C   Calasanz Maria Jose MJ   Trim Nicola N   Erber Wendy W   Sander Birgitta B   Ott German G   Rosenwald Andreas A   Colomer Dolors D   Giné Eva E   Siebert Reiner R   Lopez-Guillermo Armando A   Stamatopoulos Kostas K   Beà Sílvia S   Campo Elías E  

Cancer research 20120820 20

Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an aggressive clinical course, whereas others having an indolent behavior. We conducted an integrative and multidisciplinary analysis of 177 MCL to determine whether the immunogenetic features of the clonotypic B-cell receptors (BcR) may identify different subsets of tumors. Truly unmutated (100% identity) IGHV genes were found in 24% cases, 40% were minimally/borderline mutated (99.9%-97%), 19% significantly muta  ...[more]

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