Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [gene expression]

ABSTRACT: Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based on microarray technologies. The cell lines showed complex patterns of DNA copy number changes, where copy number gains were significantly associated with gene-rich regions of the genome and losses with gene-poor areas. Integration of the datasets showed that the mRNA levels were regulated by either alterations in DNA copy number or DNA methylation. Using a recurrence threshold of 6/19 (> 30 %) cell lines, 348 genes were identified as having alterations of two data types (gain or hypo-methylatio

ORGANISM(S): Homo sapiens

SUBMITTER: Leonardo Meza-Zepeda 

PROVIDER: E-GEOD-36001 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress