Gene expression profiles in lymph nodes from ferrets infected with A/California/07/2009

ABSTRACT: Pandemic H1N1 influenza A Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but significant number of infected individuals. Microarray analysis of the lymph nodes from ferrets infected with A/California/07/2009 shows intense gene upregulation during days 3 and 5 post-infection, and followed by marked downregulation during days 7 and 14 post infection. Gene expression profiles during the upregulation phase show intense chemokine activity, cell replication and activation of the lymphocyte-related signaling pathways. 15 ferrets were randomly allocated to 5 groups: Day 0 (before infection), and Day 3, 5, 7 and 14 (post infection) with 3 biological replicates for each group. Infection was performed with 10E6 EID50 of influenza

ORGANISM(S): Mustela putorius furo

SUBMITTER: Longsi Ran 

PROVIDER: E-GEOD-36019 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress