Transcription Factor Binding Sites by ChIP-seq from ENCODE/PSU

ABSTRACT: Rationale for the Mouse ENCODE project Our knowledge of the function of genomic DNA sequences comes from three basic approaches. Genetics uses changes in behavior or structure of a cell or organism in response to changes in DNA sequence to infer function of the altered sequence. Biochemical approaches monitor states of histone modification, binding of specific transcription factors, accessibility to DNases and other epigenetic features along genomic DNA. In general, these are associated with gene activity, but the precise relationships remain to be established. The third approach is evolutionary, using comparisons among homologous DNA sequences to find segments that are evolving more slowly or more rapidly than expected given the local rate of neutral change. These are inferred to be under

ORGANISM(S): Mus musculus

SUBMITTER: UCSC ENCODE DCC 

PROVIDER: E-GEOD-36029 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress