Expression data from melanoma subpopulations
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mario Mikula
PROVIDER: E-GEOD-36035 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MET expression in melanoma correlates with a lymphangiogenic phenotype.
Swoboda Alexander A Schanab Oliver O Tauber Stefanie S Bilban Martin M Berger Walter W Petzelbauer Peter P Mikula Mario M
Human molecular genetics 20120507 15
Melanomas contain high frequencies of tumorigenic cells and their tumorigenic capacity resides in several distinct subpopulations within melanoma. Since their metastatic potential is linked to their ability to recruit lymphatic vessels, we aimed at identifying lymphangiogenic subpopulations by comparative in vitro analysis of single cell clones derived from a melanoma of a single patient. Selected lymphangiogenic clones were then grafted into severe combined immunodeficient mice, where they indu ...[more]
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