Primary murine embryonic fibroblasts (MEFs): Cdk7 wild type versus Cdk7 KO
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David SantamarÃa
PROVIDER: E-GEOD-36050 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
Ganuza Miguel M Sáiz-Ladera Cristina C Cañamero Marta M Gómez Gonzalo G Schneider Ralph R Blasco María A MA Pisano David D Paramio Jesús M JM Santamaría David D Barbacid Mariano M
The EMBO journal 20120413 11
Cyclin-dependent kinase (Cdk)7, the catalytic subunit of the Cdk-activating kinase (CAK) complex has been implicated in the control of cell cycle progression and of RNA polymerase II (RNA pol II)-mediated transcription. Genetic inactivation of the Cdk7 locus revealed that whereas Cdk7 is completely dispensable for global transcription, is essential for the cell cycle via phosphorylation of Cdk1 and Cdk2. In vivo, Cdk7 is also indispensable for cell proliferation except during the initial stages ...[more]
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