Molecular diagnosis of T cell and/or antibody-mediated rejection in human kidney transplant biopsies

ABSTRACT: Histologic diagnosis of T cell-mediated rejection in kidney transplant biopsies has limited reproducibility because it is based on non-specific lesions using arbitrary rules that are subject to differing interpretations. We used microarray results from 403 indication biopsies previously given histologic diagnoses to develop a molecular classifier that assigned a molecular T cell-mediated rejection score to each biopsy. Independent assessment of the biopsies by multiple pathologists confirmed considerable disagreement on the presence of TCMR features: 79-88% accuracy and 35-69% sensitivity. The agreement of the molecular T cell-mediated rejection score with the histology diagnosis was similar to agreement among individual pathologists: accuracy 89%, sensitivity 51%. However, the score also

ORGANISM(S): Homo sapiens

SUBMITTER: Jessica Chang 

PROVIDER: E-GEOD-36059 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress