Comparative transcriptomics of pathogenic and non-pathogenic Listeria species

ABSTRACT: Listeria monocytogenes is a human, food-borne pathogen. Genomic comparisons between L. monocytogenes and Listeria innocua, a closely related non-pathogenic species, were pivotal in the identification of protein coding genes essential for virulence. However, no comprehensive comparison has focused on the non-coding genome. We used strand-specific cDNA sequencing to produce genome-wide transcription start site (TSS) maps for both organisms, and developed a publicly available integrative browser to visualize and analyze both transcriptomes in different growth conditions and genetic backgrounds. Our data revealed conservation across most transcripts, but significant divergence between the species in a subset of non-coding RNAs. In L. monocytogenes we identified 113 sRNAs and 70 asRNAs, signifi

ORGANISM(S): Listeria monocytogenes EGD-e

SUBMITTER: Omri Wurtzel 

PROVIDER: E-GEOD-36060 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress