Factor VII activating protease (FSAP) exerts antifibrotic effects in a mouse model of experimental liver fibrosis

ABSTRACT: Background and Rationale: Factor VII activating protease (FSAP) is a circulating serine protease produced in the liver. A single nucleotide polymorphism (G534E, Marburg I, MI-SNP) in the gene encoding FSAP (HABP2) leads to lower enzymatic activity and is associated with enhanced liver fibrosis. FSAP is activated by damaged cells and its substrates include growth factors and haemostasis proteins. We have investigated the progression of liver fibrosis in FSAP deficient mice. Results: Wild type (WT) or FSAP-/- mice were subjected to bile duct ligation (BDL) and assessment of liver fibrosis. FSAP-/- mice showed enhanced liver fibrosis and accumulation of extracellular matrix as determined by Sirius Red staining and hydroxyproline content. FSAP deficient mice exhibited stronger injury as determ

ORGANISM(S): Mus musculus

SUBMITTER: Ute Bissels 

PROVIDER: E-GEOD-36066 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress