Virus-misplaced host protein activates innate immunity

ABSTRACT: Discrimination between self vs. non-self and adequate response to infection and tissue damage are fundamental functions of the immune system. The rapid and global spread of known and emerging viruses is a testament that the timely detection of viral pathogens that reproduce within host cells, presents a formidable challenge to the immune system. To gain access to a proper reproductive niche, many pathogens travel via the host vasculature and therefore become exposed to humoral factors of the innate immune system. Although a cascade of coagulation factors plays a fundamental role in host defense for “living fossils” such as horseshoe crabs (Xiphosurida spp), the role of the coagulation system in activation of innate responses to pathogens in higher organisms remains unclear. When human type

ORGANISM(S): Mus musculus

SUBMITTER: Richard Beyer 

PROVIDER: E-GEOD-36078 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress