Genomic profiles of oxidative stress-induced rat renal cell carcinomas

ABSTRACT: Intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA) initiates Fenton reaction in the renal proximal tubules of rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated treatment. We performed high-resolution microarray comparative genomic hybridization to identify characteristics in the genomic profiles of oxidative stress-induced rat RCCs. The results revealed extensive large-scale genomic alterations with a preference for deletion. Carcinogenesis protocol was performed using male F1 hybrid rats between Fischer344 and Brown-Norway strains. 13 primary tumors and 2 cell lines of Fe-NTA induced RCCs were profiled on Agilent 185K rat genome CGH microarrays. One RCC sample of a female Eker rat was also analyzed with the same Agilent 185K ra

ORGANISM(S): Rattus norvegicus

SUBMITTER: Shinya Toyokuni 

PROVIDER: E-GEOD-36101 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress