Deep sequencing the circadian and light-dependent transcriptome of Drosophila brain

ABSTRACT: Eukaryotic circadian clocks include transcriptional/translational feedback loops that drive 24-hour rhythms of transcription.These transcriptional rhythms underlie oscillations of protein abundance, thereby mediating circadian rhythms of behavior, physiology, and metabolism. Numerous studies over the last decade have employed microarrays to profile circadian transcriptional rhythms in various organisms and tissues. Here we use RNA sequencing (RNA-Seq) to profile the circadian transcriptome of *Drosophila melanogaster* brain from wild-type and *period*-null clock-defective animals. We identify several hundred transcripts whose abundance oscillates with 24-hour periods, including a number of non-coding RNAs (ncRNAs) that were not identified in previous microarray studies. Of particular inter

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Michael Hughes 

PROVIDER: E-GEOD-36108 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress