Platelet-derived growth factor-alpha (PDGF-α) stimulates intestinal epithelial cell turnover after massive small bowel resection in a rat

ABSTRACT: Numerous cytokines have been shown to affect epithelial cell differentiation and proliferation through epithelial-mesenchymal interaction. Growing evidence suggests that platelet-derived growth factor (PDGF) signaling is an important mediator of these interactions. The purpose of this study was to evaluate the effect of PDGF-α on enterocyte turnover in a rat model of short bowel syndrome (SBS). Male rats were divided into four groups: Sham rats underwent bowel transection, Sham-PDGF-α rats underwent bowel transection and were treated with PDGF-α, SBS rats underwent a 75% bowel resection, and SBS-PDGF-α rats underwent bowel resection and were treated with PDGF-α. Parameters of intestinal adaptation, enterocyte proliferation and apoptosis were determined at sacrifice. Illumina's Digital Gene

ORGANISM(S): Rattus norvegicus

SUBMITTER: Igor Sukhotnik 

PROVIDER: E-GEOD-36122 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress