DNA Methylation Profiling Defines Clinically Relevant Biological Subsets of Non-small Cell Lung Cancer

ABSTRACT: PURPOSE: Non-small cell lung cancers (NSCLC) comprise multiple distinct biological groups with different prognoses. For example, patients with epithelial-like (EL) tumors have a better prognosis and exhibit greater sensitivity to inhibitors of the epidermal growth factor receptor (EGFR) pathway than patients with mesenchymal-like (ML) tumors. Here we test the hypothesis that EL NSCLCs can be distinguished from ML NSCLCs on the basis of global DNA methylation patterns. EXPERIMENTAL DESIGN: To determine whether phenotypic subsets of NSCLC can be defined based on their DNA methylation patterns, we combined microfluidics-based gene expression analysis and genome-wide methylation profiling. We derived robust classifiers for both gene expression and methylation in cell lines and tested these cl

ORGANISM(S): Homo sapiens

SUBMITTER: David Shames 

PROVIDER: E-GEOD-36216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress