Tuberculosis Patients Blood Gene Expression Through Treatment (cured and end-of-treatment patients)

ABSTRACT: Background Accurate assessment of treatment efficacy would facilitate clinical trials of new anti-tuberculosis drugs. TB patients exhibit altered peripheral immunity which reverts during successful treatment. We hypothesised that these changes could be observed in whole blood transcriptome profiles. Methods Ex vivo blood samples from 27 pulmonary TB patients were assayed at diagnosis and during conventional treatment. RNA was processed and hybridised to Affymetrix GeneChips, to determine expression of over 47,000 transcripts. Findings There were significant changes in expression of over 4,000 genes during treatment. Rapid, large scale changes were detected, with down-regulated expression of ~1,000 genes within the first week, including inflammatory markers such as the complement compo

ORGANISM(S): Homo sapiens

SUBMITTER: Jackie Cliff 

PROVIDER: E-GEOD-36238 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress