MicroRNA profiling of the failing heart after myocardial infarction induction and doxorubicin treatment

ABSTRACT: The use of anthracycline antibiotics such as doxorubicin (DOX) has greatly improved the mortality and morbidity of cancer patients. However, the associated risk of cardiomyopathy has limited their clinical application. DOX-associated cardiotoxicity is irreversible and progresses to heart failure (HF). For this reason, a better understanding of the molecular mechanisms underlying these adverse cardiac effects is essential to develop improved regimes that include cardioprotective strategies. MicroRNAs (miRNAs) are short non-coding RNAs that are able to post-trascriptionally regulate gene expression. MiRNAs have been demonstrated to be involved in both cancer and cardiovascular disease. Therefore, we were interested in unveiling the potential role of miRNAs in chemotherapy-induced HF. We used

ORGANISM(S): Rattus norvegicus

SUBMITTER: Laura Roca-Alonso 

PROVIDER: E-GEOD-36239 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress