Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (RNA-Seq)

ABSTRACT: Whole-genome transcriptome measurements are pivotal for characterizing carcinogenic mechanisms of chemicals and predicting toxic classes, such as genotoxicity, from in vitro and in vivo assays. DNA microarrays have evolved as the gold standard for this purpose. In recent years deep sequencing technologies have been developed that hold the promise of measuring the transcriptome with RNA-seq in a more accurate and unbiased manner than microarrays. So far, however, few applications have been published that assess the performance of RNA-seq within a toxicogenomics context. Here, we applied RNA-seq for the characterization of the in vitro transcriptomic responses in HepG2 cells upon exposure to benzo[a]pyrene (BaP), a well-known DNA damaging carcinogen. We demonstrate the performance of RNA-seq

ORGANISM(S): Homo sapiens

SUBMITTER: Stan Gaj 

PROVIDER: E-GEOD-36242 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress