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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from murine liver tissue upon depletion of regulatory T cells

ABSTRACT: Regulatory T cells (Treg) play a pivotal role in modulating immune responses and were shown to decrease atherosclerosis in murine models. How this effect is brought about remains elusive. We used microarrays to detail the global programme of gene expression in liver tissue from chimeric DEREG x Ldlr-/- mice +/- diphteria toxin enabling selective depletion of Treg. Chimeric DEREG x Ldlr-/- mice were kept on a high fat diet for 8 weeks and treated with DT (vehicle) or PBS (placebo) i.p. for 8 weeks. Upon harvest, liver tissue was ascertained from animals from both groups and a gene array was performed.

ORGANISM(S): Mus musculus

SUBMITTER: Stefan Zoller

PROVIDER: E-GEOD-36279 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from murine intestinal tissue upon depletion of regulatory T cells

Project description:Regulatory T cells (Treg) play a pivotal role in modulating immune responses and were shown to decrease atherosclerosis in murine models. How this effect is brought about remains elusive. We used microarrays to detail the global programme of gene expression in intestinal tissue from chimeric DEREG x Ldlr-/- mice +/- diphteria toxin enabling selective depletion of Treg. Chimeric DEREG x Ldlr-/- mice were kept on a high fat diet for 8 weeks and treated with DT or PBS i.p. for 8 weeks. Upon harvest, intestinal tissue was ascertained from animals from both groups and a gene array was performed.

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Expression data from murine intestinal tissue upon depletion of regulatory T cells

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Expression data from murine liver tissue upon depletion of regulatory T cells

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Gene expression data from mouse regulatory T cells

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2023-03-15 | E-MTAB-12669 | biostudies-arrayexpress

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Attenuation of early atherogenesis in LDLR-KO mice by proteasome inhibition

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Regulatory T cells suppress the formation of super-effector CD8 T cells by limiting IL-2

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