Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

A PGC-1alpha-dependent decrease in mitochondrial oxidative metabolism in muscle of humans with inherited insulin resistance

ABSTRACT: We used microarrays to assess gene expression profiling of 6 patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR) and 10 matched healthy controls Total RNA was purified from skeletal muscle and amplified to biotin-labeled aRNA and hybridized to microarray chips.

ORGANISM(S): Homo sapiens

SUBMITTER: Vibe Skov 

PROVIDER: E-GEOD-36297 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance.

Kristensen Jonas M JM   Skov Vibe V   Petersson Stine J SJ   Ørtenblad Niels N   Wojtaszewski Jørgen F P JF   Beck-Nielsen Henning H   Højlund Kurt K  

Diabetologia 20140209 5

<h4>Aims/hypothesis</h4>Insulin resistance in obesity and type 2 diabetes is related to abnormalities in mitochondrial oxidative phosphorylation (OxPhos) in skeletal muscle. We tested the hypothesis that mitochondrial oxidative metabolism is impaired in muscle of patients with inherited insulin resistance and defective insulin signalling.<h4>Methods</h4>Skeletal muscle biopsies obtained from carriers (n = 6) of a mutation in the tyrosine kinase domain of the insulin receptor gene (INSR) and matc  ...[more]

Similar Datasets

Transcriptomics A PGC-1alpha-dependent decrease in mitochondrial oxidative metabolism in muscle of humans with inherited insulin resistance
2014-02-17 | GSE36297 | GEO
Transcriptomics Mitochondrial biogenesis induced by PGC-1alpha
2006-04-03 | GSE4330 | GEO
Transcriptomics Analysis of TLS activity in PGC-1alpha+/+ and PGC-1alpha-/- hepatocytes
2013-07-26 | E-GEOD-23242 | biostudies-arrayexpress
Unknown The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis.
| S-EPMC404069 | biostudies-literature
Transcriptomics Pyruvate induces mitochondrial biogenesis by a PGC-1alpha independent mechanism
2006-08-12 | GSE5497 | GEO
Transcriptomics Analysis of TLS activity in PGC-1alpha+/+ and PGC-1alpha-/- hepatocytes
2013-07-26 | GSE23242 | GEO
Unknown PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells.
| S-EPMC2632715 | biostudies-literature
Unknown PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle.
| S-EPMC2504883 | biostudies-other
Unknown Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells.
| S-EPMC2700944 | biostudies-literature
Unknown Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.
| S-EPMC1847661 | biostudies-literature