Global changes in gene expression in dermal fibroblasts with in vivo and in vitro deletion of the RBP-Jk gene

ABSTRACT: It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a cause or consequence of cancer. Here, we provide evidence that loss of mesenchymal Notch/CSL signaling causes tissue alterations, including stromal atrophy and inflammation, which precede and are potent triggers for epithelial tumors. Mice carrying a mesenchymal-specific deletion of CSL/RBP-JK, a key Notch effector, exhibit spontaneous multifocal keratinocyte tumors that develop after dermal atrophy and inflammation. CSL-deficient dermal fibroblasts promote increased tumor cell proliferation through up-regulation of c-Jun and c-Fos expression and consequently higher levels of diffusible growth factors, inflammatory cytokines, and matrix remodeling enzymes. In human skin samples, stromal fields adj

ORGANISM(S): Mus musculus

SUBMITTER: giovanna chiorino 

PROVIDER: E-GEOD-36359 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress