Synaptic activity-regulated gene expression_embryonic day 18

ABSTRACT: Activity-dependent changes in synapses rely on functional changes in resident proteins and on gene expression. We addressed the relationship between synapse activity and the expression of synaptic genes by comparing RNA levels in the neocortex of normal mice versus synaptically silent munc18-1 null mutants, using microarray expression analysis, quantitative PCR and Northern blotting. We hypothesized that genes under control of synaptic activity are differentially expressed between mutants and controls and found that few synaptic signaling genes were differentially expressed. However, all neuropeptide genes with detectable expression on the microarray were differentially expressed, being 3-20 fold higher in control cortex. Genes encoding their receptors and most other synaptic components we

ORGANISM(S): Mus musculus

SUBMITTER: Jildau Bouwman 

PROVIDER: E-GEOD-3639 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress